Cannabinoids

Cannabinoids are a diverse class of chemical compounds that interact with the endocannabinoid system (ECS) in the body, influencing physiological processes such as pain, mood, appetite, sleep, and immune function. These compounds can be derived naturally from the Cannabis sativa plant, synthesized in laboratories, or produced semi-synthetically by modifying natural cannabinoids. Their effects range from psychoactive experiences to therapeutic applications.

The cannabinoid market in the US has evolved from the prohibition of cannabis to the widespread availability of natural, synthetic, and semi-synthetic cannabinoids. This growth has been fueled by changing legal frameworks, consumer interest in wellness products, and advancements in cannabinoid science. While cannabinoids offer significant therapeutic potential, the rise of unregulated products, particularly synthetics, underscores the need for careful oversight and consumer education.

Below is a list of common, or historically common, cannabinoids which can be used as a starting point for further research. Please note that some of the cannabinoids listed here may only have limited information available about them online, and be mindful of the fact that Rise Above The Risk may be privy to information that only a very small number of people have on some (but not all) of these cannabinoids due to first hand experience prior to changes in the legal framework restricting access to these substances. So, if you have any questions regarding the cannabinoids listed here (or that you have discovered elsewhere) that are not directly answered by the outside resource(s) linked to here (or by whatever resource(s) you utilized to find the cannabinoid(s) not listed here,) then feel free to reach out to Rise Above The Risk to have those questions answered to the best of our ability.

Questions regarding the development of the synthetic cannabinoid market, as well as the legal history behind synthetic cannabinoids can be answered by reaching out as well.

Natural Cannabinoids
These cannabinoids are naturally found in the Cannabis plant in appreciable amounts.

Semi-Synthetic Cannabinoids
These cannabinoids are either naturally occurring in trace amounts and primarily synthesized for practical use or are chemically modified versions of natural cannabinoids.

Synthetic Cannabinoids

These cannabinoids are entirely man-made and do not occur naturally in the Cannabis plant.

First Generation
These were the initial synthetic cannabinoids developed, often based on classical cannabinoid structures.

Second Generation
Developed as alternatives to first-generation compounds, often with slight modifications to enhance potency or evade legal restrictions.

Third Generation
These represent the most recent and complex synthetic cannabinoids, designed for increased potency, altered effects, and to circumvent existing regulations.